Over the span of millions or billions of years, mankind may be destroyed, only to re-emerge through another cycle of new humanity.
Immediate future is androids, evolving into one connected mind which will be the God of distance future creating and guiding future life forms.
We are going to keep evolving and spray out into the galaxy like the spores of a mushroom. Our diaspora will live on multiple worlds, will keep evolving and space will bloom with our biodiversity. It might have already done so.